Grape Seed Extract Drug Interactions

Theoretically, anticoagulant or antiplatelet medications could cause drug interactions with grape seed extract. Such interactions may occur if the supplement is taken in combination with aspirin, heparin, nonsteroidal anti-inflammatory drugs, or warfarin. These interactions could possibly increase your risk of bleeding, including dangerous internal bleeding. However, the risk may be more serious with potent prescription drugs and less dangerous with drugs like NSAIDs.

An Introduction to Grape Seed Extract Drug Interactions

Even though it is a natural product, grape seed extract can potentially interact with a few medicines. At this time, these interactions are only theoretical; there is no real evidence that such interactions may really be a problem. In particular, it is thought that grape seed extract could interact with anticoagulant or antiplatelet medications ("blood thinners"), such as:
 
  • Aspirin (Bayer® and others)
  • Cilostazol (Pletal®)
  • Clopidogrel (Plavix®)
  • Dipyridamole (Persantine®)
  • Eptifibatide (Integrilin®)
  • Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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