Lucentis is approved to treat macular edema and wet age-related macular degeneration. At this time, there are no universally accepted "off-label" uses for Lucentis, and the medicine is not approved for use in children.
Lucentis® (ranibizumab) is a prescription medication that is injected directly into the eye. It is approved for the treatment of the following conditions:
- Wet age-related macular degeneration (also known as neovascular macular degeneration)
- Macular edema due to retinal vein occlusion
- Diabetic macular edema.
Using Lucentis for Macular DegenerationAge-related macular degeneration (AMD, or just macular degeneration) is a common eye disease associated with aging. It blurs the sharp, central vision you need for "straight-ahead" activities, such as reading or driving (see Macular Degeneration and Driving). The causes of macular degeneration are unknown. However, certain risk factors (such as smoking and obesity) increase the likelihood of developing the disease. Macular degeneration may be genetic to some extent as well (see Macular Degeneration Genetics).
If the loss of these light-sensing cells in the macula becomes great, people may see a small (but growing) blind spot in the middle of their field of vision. Over time, the blurred spot may get bigger and darker, taking up more of your central vision. You may have difficulty reading or recognizing faces until they are very close to you.
There are two types of macular degeneration. About 90 percent of people with macular degeneration have what's known as the "dry" type, and the remaining 10 percent have the "wet" type. However, wet macular degeneration accounts for 90 percent of all blindness associated with the disease.
In wet macular degeneration, new blood vessels grow behind the macula. Because these new blood vessels tend to be very fragile, they will often leak blood and fluid under the macula. This causes rapid damage to the macula, which can lead to the loss of central vision in a short period of time. Wet macular degeneration symptoms include straight lines appearing crooked and a blind spot in the center of your vision.
Loss of central vision can occur quickly. Wet macular degeneration is a more advanced form of the disease, and is more severe than dry macular degeneration.
Wet macular degeneration treatment may include:
- Photodynamic therapy
- Laser surgery (see Surgery for Macular Degeneration)
- Injections (including Lucentis).