Macular Degeneration Home > Eylea Side Effects

If you are receiving injections of Eylea, you may develop eye pain, increased pressure in the eye, or blood spots on the white part of the eye. While most side effects of Eylea tend to be minor and easily treated, contact your healthcare provider right away if you experience more serious problems, such as eye infections or a sudden decrease in vision.

An Introduction to Eylea Side Effects

Just like any medicine, Eylea™ (aflibercept) can cause side effects. However, not everyone who receives the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Eylea. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Eylea

Eylea has been studied extensively. In these studies, some of the people were treated with Eylea, while others were treated with ranibizumab (Lucentis®), a similar medication that is also injected into the eye. The side effects that occurred in the two groups were carefully documented and compared.
In these studies, the most common Eylea side effects included:
  • Blood spots on the white part of the eye -- in up to 25 percent of people
  • Eye pain -- up to 13 percent
  • Increased pressure in the eye -- up to 8 percent
  • Cataracts -- up to 7 percent
  • Vitreous detachment (a common and usually harmless eye change that can result in "floaters" in the vision) -- up to 6 percent
  • "Floaters" in the vision -- up to 6 percent.
Other common reactions, occurring in 1 to 5 percent of people, included:
  • Red eyes
  • Erosion of the cornea
  • Detachment of the retinal pigment epithelium (a common finding in people with macular degeneration)
  • Pain at the injection site
  • Feeling like something is stuck in the eye
  • Blurred vision
  • Watery eyes
  • Swelling of the eye or eyelid
  • Bleeding at the injection site
  • Retinal pigment epithelium tear (tears in certain eye tissue).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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